Top NAD Supplements of 2025, Expert-Approved

Understanding NAD and Its Role in Healthspan

Nicotinamide adenine dinucleotide, or NAD, is a naturally occurring molecule found in every cell of the human body. It plays a crucial role in various cellular processes, including energy production, DNA repair, and maintaining overall cell health. As we age, levels of NAD in our bodies tend to decline, which has led researchers to explore whether supplementing with NAD might help counteract some of the effects of aging.

“It's a reasonable hypothesis that the declines in NAD might contribute to disease and dysfunction as we age, and that supplementing NAD would be a way to restore it and improve our health holistically,” says Daniel Craighead, PhD, who has published research on NAD-boosting compounds.

Studies on animals have shown that giving them NAD precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) can improve several biomarkers for cardiovascular health, brain function, metabolism, muscle health, and skin anti-aging. However, while these results are promising, the research on humans is still limited, and the findings so far have been mixed.

“It's important to have a big picture of health — we stress whole foods, exercise, sleep hygiene, stress reduction, those things first,” says Barry Sandler, DO, an osteopathic physician specializing in anti-aging medicine at Vail Health. “But I think NAD is safe and looks promising for most people.” He and other experts recommend that anyone interested in taking NAD supplements check with their physician first.

The Challenge of NAD Supplementation

NAD itself is a large molecule, which means it cannot enter cells directly. Experts are skeptical of NAD IV drips and anything that claims to contain actual NAD due to the size of the molecule and the fact that NAD can’t survive outside certain conditions. Instead, the best way to maximize natural NAD production in the body is by boosting its precursors.

The tricky part, however, is that supplements containing these precursors aren’t regulated by the Food and Drug Administration (FDA), making it difficult to determine which products are effective and safe. “A study came out where they randomly sampled NMN supplements on the market, and most had much less of the ingredient than advertised,” Dr. Craighead says. And since these capsules aren’t cheap, you want to be sure you get what you’re paying for.

Top NAD Supplements for 2025

Here are some of the top NAD supplements recommended by experts:

Pure Encapsulations NR Longevity

Main ingredient: Niagen - nicotinamide riboside chloride (NR)
Dosage: 300mg
Other active ingredients: Broccoli sprout concentrate, trans-resveratrol
Capsules per container: 30

Why we love it: Trustworthy brand, third-party tested, used by healthcare providers themselves, vegan, gluten-free, non-GMO, includes antioxidants, odorless and flavorless according to reviews.

Take note: Not ideal for those sensitive to resveratrol.

As a major fan of NAD supplementation, Amanda Kahn, MD, an internal medicine physician specializing in longevity, says the Pure Encapsulations NR longevity supplements are what she herself reaches for daily. “They provide a lot of background for why they formulated the way they have and the dose that they picked,” she says. For example, unlike Tru Niagen, which just offers NR, Pure Encapsulations’ formula also includes antioxidants like trans-resveratrol, and explains the science behind why.

Buy now £59.9, iHerb.com

Axia Cellenial

Main ingredient: Nicotinic acid (NA)
Dosage: 70mg
Other active ingredients: L-citrulline and alpha ketoglutarate, berberine, acetyl l-carnitine, r-lipoic acid, garlic extract, black pepper extract
Capsules per container: 60

Why we love it: Offers a host of antioxidants, third-party tested, gluten-free, dairy-free, nut-free, non-GMO.

Take note: Features nicotinic acid (NA) rather than NR or NMN.

Axia’s cellenial supplement is more than just an NAD precursor. “It also has antioxidants, with some berberine in it, r-lipolic acid, and garlic extract,” says Ontario-based naturopathic doctor Maille Devlin, ND. That means that rather than only targeting NAD levels, it also has a lipid-lowering impact. “It has things that increase HDL, the healthy cholesterol,” says Dr. Devlin. Rather than NR or NMN, Cellennial uses another NAD booster, nicotinic acid (NA) — a different precursor that’s not quite as popular. But Dr Devlin still thinks this offers a great formulation. “Overall, if someone's looking for a longevity supplement, I would suggest something like this where it's not just targeting one thing,” she says.

Buy now £32.95, Axialongevity.com

Tru Niagen 300mg

Main ingredients: Niagen – nicotinamide riboside chloride (NR)
Dosage: 300mg
Other active ingredients: None
Capsules per container: 30

Why we love it: Science-based brand, main ingredient supported by over 40 human clinical peer-reviewed studies, subscribing and buying in bulk can bring the cost down to about $32.50, full dose in one capsule, third-party tested, vegetarian, gluten-free, allergy-free, kosher, halal.

Take note: No other active ingredients included.

Tru Niagen is another top recommendation that Dr. Kahn trusts, thanks to rigorous clinical research behind its main ingredient, niagen NR. It’s also one of the lowest-cost options around: By subscribing and buying six months’ worth at a time, you can bring the price down to about $39.50 for 30 servings, or just over $1 a day. The brand also offers a few different variations. Those who want to go all in on NR can opt for a 1000mg dose. And those who have a hard time swallowing pills can get smaller ones with 150 mg of NR (though you need to take two capsules to get a full serving) or a powder you can mix into water. Just know that, unlike Pure Encapsulations, these pills have no other active ingredients like antioxidants, though the powder does come with prebiotic fiber.

Buy now £36.75, Truniagen.com

Elysium Basis

Main ingredient: Patent-pending crystalline nicotinamide riboside (NR-E)
Dosage: 250mg
Other active ingredients: Pterostilbene
Capsules per container: 60

Why we love it: Research-backed, can be bundled with Mosaic for skin health, third-party tested, NSF Certified for Sport, buying an annual subscription brings the price down to $40 per bottle, vegan, gluten-free, nut-free, and no artificial colors, contains pterostilbene, which has been found to counter skin aging, small capsules easy to swallow, according to reviews.

Take note: Uses patent-pending crystalline nicotinamide riboside (NR-E).

Because NAD supplements reduce overall inflammation, some of the effects can be aesthetic. “Patients report that their skin looks brighter,” Dr. Kahn says. If skin health is your primary goal, she recommends looking into the research-backed Elysium basis, which is offered as part of a bundle ($199, Elysiumhealth.com) along with the brand’s mosaic supplement for protection against skin aging. Buying the two this way brings the price down to $100 per month for both. Bonus: In addition to NR, basis also includes pterostilbene, the antioxidant in blueberries that’s been found to improve skin elasticity and firmness, and reduce wrinkles. Just know that the active ingredient here is NR-E, a patent-pending crystalline version of NR, though it’s been shown to be just as safe.

Buy now £65, Elysiumhealth.com

Choosing the Right NAD Supplement

For a tried-and-true, expert-trusted NAD supplement, Pure Encapsulations’ NR longevity is your best buy. However, if budget is top of mind for you, Tru Niagen is another option backed by solid research, and it comes in buying options that bring the price down to just a little over a dollar a day. Axia cellenial also gets high ratings from one doctor we interviewed, thanks to the way it combines an NAD booster with a hefty dose of antioxidants. Whichever option you go with, just make sure to always look for third-party testing and stick with a reputable brand.

What Is NAD?

“Nicotinamide adenine dinucleotide (NAD) is a vital enzyme that supports several key cellular processes, including energy production, DNA repair, and overall cell health. An enzyme is a special type of protein that helps chemical reactions happen faster in the body. You can think of enzymes like tiny machines or tools inside your cells — they speed up important processes, such as breaking down food for energy, building new molecules, or repairing damage,” explains Kristen Smith, MS, RDN and Spokesperson for the Academy of Nutrition and Dietetics.

Do NAD Supplements Work?

“Research on the benefits of NAD supplementation for heart, metabolic, and physical health is still limited. More and larger studies are needed to confirm its effectiveness, identify the best dose and duration, and determine which groups may benefit the most,” Smith tells The Independent.

Why You Can Trust IndyBest U.S. Reviews

Jennifer Heimlich has more than a decade of experience as a journalist within the wellness industry, so she is a reliable and knowledgeable voice when it comes to recommendations. When not writing, she’s a UESCA-certified running coach and hosts running tours, so she takes health and fitness seriously. To help guide you to the best NAD supplements, she’s consulted researchers and doctors on what to look for and the top options they personally recommend.